Microbiological Profile of Adenoid Hypertrophy Correlates to Clinical Diagnosis in Children
نویسندگان
چکیده
OBJECTIVE Adenoid hypertrophy is a common condition in childhood, which may be associated with recurring acute otitis media (RAOM), otitis media with effusion (OME), and obstructive sleep apnea syndrome (OSAS). These different clinical characteristics have some clinical overlap; however, they might be explained by distinct immunologic and infectious profiles and result in various histopathologic findings of adenoid specimens. METHODS A total of 59 children with adenoid hypertrophy undergoing adenoidectomy were studied. Three series of identical adenoid specimens were processed to hematoxylin-eosin (H.E.) and Gram staining and to respiratory virus specific real-time PCR, respectively. RESULTS According to the clinical characteristics, patients were recruited into three groups: RAOM (n = 25), OME (n = 19), and OSAS (n = 15). Bacterial biofilms were detected in 21 cases, while at least one of the studied respiratory viruses was detected in 52 specimens. RAOM cases were significantly associated with biofilm existence (n = 20, P < 0.001). In contrast, OME group was characterized by the absence of bacterial biofilm and by normal mucosa. Showing a statistically significant correlation, all OME cases were positive for human bocavirus (HBoV, P < 0.001). CONCLUSIONS Bacterial biofilms might contribute to the damage of respiratory epithelium and recurring acute infections resulting in RAOM. In OME cases persisting respiratory viruses, mainly HBoV, can cause subsequent lymphoid hyperplasia leading to ventilation disorders and impaired immunoreactivity of the middle ear cleft.
منابع مشابه
Investigating the frequency of adenoid hypertrophy and allergic rhinitis in children with mouth breathing complaints
Background and Objectives: Nocturnal snoring and open mouth breathing in children is one of the common causes of referrals to pediatricians. The two most common reasons of this problem are adenotonsillar hypertrophy and allergic rhinitis. Based on the findings, there is still no significant relationship between these two diseases. Therefore, the aim of this study was to determine the frequency ...
متن کاملA New Clinical Scoring System for Adenoid Hypertrophy in Children
Introduction: Chronic nasal obstruction due to adenoid hypertrophy is a very common disorder. Although the clinical assessment of adenoid hypertrophy is essential, its real value in young children is difficult to evaluate. The purpose of this prospective study was to validate a simple clinical score to predict the severity of adenoid obstruction and to evaluate the relationship between this met...
متن کاملEffects of intranasal corticosteroids on decrease of adenoid hypertrophy in children
Introduction: Adenoid hypertrophy is associated with high morbidity rate in children. Although surgical treatment is indicated in severe cases, but there are evidences that some medical interventions are effective in improvement. This study was conducted to evaluate the effectiveness of corticosteroid nasal spray on reduction of airway obstruction due to adenoid hypertrophy. Methods: In a clini...
متن کاملThe relationship between serum vitamin D level and adeno-tonsillar hypertrophy in children
Background: Vitamin D deficiency can cause frequent infection of tonsil and adenoid. Recurrent upper airway infections are associated with hypertrophy of lymphoid tissues (adenoid and palatine tonsils) in children. Obstructive sleep disorders, failure to thrive, facial deformity, and cognitive disorders are among the most important complications of adenotonsillar hypertrophy. Surgery is indicat...
متن کاملMontelukast in Adenoid Hypertrophy: Its Effect on Size and Symptoms
Introduction: Adenotonsillar hypertrophy (AH) is considered the most common cause of upper respiratory tract obstruction among children. It results in a spectrum of symptoms from mouth breathing, nasal obstruction, hyponasal speech, snoring, and obstructive sleep apnea (OSA) to growth failure and cardiovascular morbidity. Adenotonsillectomy is a typical strategy for patients with AH, but may le...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
دوره 2013 شماره
صفحات -
تاریخ انتشار 2013